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KMID : 1094720140190020363
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Biotechnology and Bioprocess Engineering
2014 Volume.19 No. 2 p.363 ~ p.368
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Chemopreventive activity of Cnidii Rhizoma for breast cancer
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Nam Kyung-Soo
Ha Byung-Geun
Shon Yun-Hee
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Abstract
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Chemopreventive potential for human breast cancer was assessed in vitro with Cnidii Rhizoma extract. Cnidii Rhizoma inhibited cell proliferation in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) human breast carcinoma cell lines. Cytochrome P450 (CYP) 1A1-mediated ethoxyresorufin O-deethylase (EROD) activity was inhibited by Cnidii Rhizoma in a concentration-dependent manner. In addition, Cnidii Rhizoma extract caused inhibition of microsomal aromatase (estrogen synthase) activity. Ornithine decarboxylase (ODC) activity was reduced to 40.3% of the control after 6 h treatment with Cnidii Rhizoma (5 mg/mL) in MCF-7 breast cancer cells. Cnidii Rhizoma extract markedly reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated matrix metalloproteinase (MMP)-9 activity. These results suggest that Cnidii Rhizoma could be of therapeutic value in preventing human breast cancer.
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KEYWORD
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aromatase, breast cancer, Cnidii Rhizoma, cytochrome P450 1A1, matrix metalloproteinase, ornithine decarboxylase
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